Item Type | Name |
Concept
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Bacterial Outer Membrane Proteins
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Concept
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DNA-Binding Proteins
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Concept
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Membrane Proteins
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Concept
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Nerve Tissue Proteins
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Concept
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Monosaccharide Transport Proteins
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Concept
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Heat-Shock Proteins
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Concept
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Muscle Proteins
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Concept
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Protein Precursors
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Concept
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Protein Binding
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Concept
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Protein Conformation
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Concept
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Proto-Oncogene Proteins
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Concept
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Proteins
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Concept
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Thyroxine-Binding Proteins
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Concept
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Protein Biosynthesis
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Concept
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Protein Subunits
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Concept
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Cysteine Proteinase Inhibitors
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Concept
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Protein Structure, Tertiary
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Concept
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RNA-Binding Proteins
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Concept
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MyoD Protein
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Concept
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HSP70 Heat-Shock Proteins
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Concept
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ras Proteins
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Concept
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Apoptosis Regulatory Proteins
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Concept
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Multidrug Resistance-Associated Proteins
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Concept
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Drosophila Proteins
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Concept
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Protein Tyrosine Phosphatases
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Concept
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Protein Structure, Secondary
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Concept
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Protein Folding
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Concept
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Intercellular Signaling Peptides and Proteins
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Concept
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Green Fluorescent Proteins
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Concept
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HSC70 Heat-Shock Proteins
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Concept
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Proto-Oncogene Proteins c-raf
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Concept
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WT1 Proteins
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Concept
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Recombinant Proteins
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Concept
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Protein Phosphatase 1
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Concept
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Sterol Regulatory Element Binding Protein 1
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Concept
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Adaptor Proteins, Signal Transducing
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Concept
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Sex-Determining Region Y Protein
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Concept
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GTP-Binding Proteins
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Concept
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Homeodomain Proteins
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Concept
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HSP90 Heat-Shock Proteins
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Concept
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Macrophage Inflammatory Proteins
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Concept
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Tumor Suppressor Proteins
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Concept
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Glycine Plasma Membrane Transport Proteins
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Concept
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Mutant Proteins
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Concept
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Transcription Factor 7-Like 2 Protein
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Concept
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Agouti Signaling Protein
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Concept
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AMP-Activated Protein Kinases
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Concept
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Insulin Receptor Substrate Proteins
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Concept
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LIM-Homeodomain Proteins
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Concept
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Intracellular Signaling Peptides and Proteins
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Concept
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Calcium-Binding Proteins
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Concept
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Carrier Proteins
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Concept
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Luminescent Proteins
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Concept
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Neoplasm Proteins
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Concept
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Nuclear Proteins
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Concept
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Recombinant Fusion Proteins
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Concept
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Cyclic AMP-Dependent Protein Kinases
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Concept
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Protein Isoforms
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Concept
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Protein Array Analysis
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Concept
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Proto-Oncogene Proteins c-akt
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Academic Article
|
Pharmacological properties of two cloned somatostatin receptors.
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Academic Article
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Hormonal/metabolic regulation of the human GLUT4/muscle-fat facilitative glucose transporter gene in transgenic mice.
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Academic Article
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Human insulin receptor substrate-1 gene (IRS1): chromosomal localization to 2q35-q36.1 and identification of a simple tandem repeat DNA polymorphism.
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Academic Article
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Human GLUT4/muscle-fat glucose-transporter gene. Characterization and genetic variation.
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Academic Article
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Leptin, the obese gene product, rapidly modulates synaptic transmission in the hypothalamus.
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Academic Article
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Novel MODY3 mutations in the hepatocyte nuclear factor-1alpha gene: evidence for a hyperexcitability of pancreatic beta-cells to intravenous secretagogues in a glucose-tolerant carrier of a P447L mutation.
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Academic Article
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Rat inwardly rectifying potassium channel Kir6.2: cloning electrophysiological characterization, and decreased expression in pancreatic islets of male Zucker diabetic fatty rats.
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Academic Article
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JAK/STAT eats the fat.
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Academic Article
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Mammalian facilitative glucose transporters: evidence for similar substrate recognition sites in functionally monomeric proteins.
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Academic Article
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Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3)
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Academic Article
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Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)
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Academic Article
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Mutations in the hepatocyte nuclear factor-1alpha gene in MODY and early-onset NIDDM: evidence for a mutational hotspot in exon 4.
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Academic Article
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Searching for NIDDM susceptibility genes: studies of genes with triplet repeats expressed in skeletal muscle.
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Academic Article
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Cloning and characterization of exodus, a novel beta-chemokine.
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Academic Article
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Hepatic function in a family with a nonsense mutation (R154X) in the hepatocyte nuclear factor-4alpha/MODY1 gene.
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Academic Article
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Molecular analysis of the fructose transporter gene (GLUT5) in isolated fructose malabsorption.
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Academic Article
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Human Oct3 gene family: cDNA sequences, alternative splicing, gene organization, chromosomal location, and expression at low levels in adult tissues.
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Academic Article
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Increase in serum leptin and uterine leptin receptor messenger RNA levels during pregnancy in rats.
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Academic Article
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Mutations in the hepatocyte nuclear factor-1alpha/MODY3 gene in Japanese subjects with early- and late-onset NIDDM.
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Academic Article
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Identification of nine novel mutations in the hepatocyte nuclear factor 1 alpha gene associated with maturity-onset diabetes of the young (MODY3).
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Academic Article
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Genetic variation in the hepatocyte nuclear factor-1 alpha gene in Danish Caucasians with late-onset NIDDM.
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Academic Article
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Activation of a protein tyrosine phosphatase and inactivation of Raf-1 by somatostatin.
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Academic Article
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Nature or nurture: an insightful illustration from a Chinese family with hepatocyte nuclear factor-1 alpha diabetes (MODY3)
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Academic Article
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Mutations in the coding region of the neurogenin 3 gene (NEUROG3) are not a common cause of maturity-onset diabetes of the young in Japanese subjects.
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Academic Article
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Abnormal nephron development associated with a frameshift mutation in the transcription factor hepatocyte nuclear factor-1 beta.
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Academic Article
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Linkage analysis of maturity-onset diabetes of the young with microsatellite polymorphisms. No linkage to ADA or GLUT2 genes in two families.
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Academic Article
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beta-cell transcription factors and diabetes: no evidence for diabetes-associated mutations in the gene encoding the basic helix-loop-helix transcription factor neurogenic differentiation 4 (NEUROD4) in Japanese patients with MODY.
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Academic Article
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Expression and regulation of the human GLUT4/muscle-fat facilitative glucose transporter gene in transgenic mice.
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Academic Article
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A simple test for the high-frequency P291fsinsC mutation in the HNF1 alpha/MODY3 gene.
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Academic Article
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A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance.
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Academic Article
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Relationship of insulin receptor substrate-1 and -2 genotypes to phenotypic features of polycystic ovary syndrome.
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Academic Article
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Reduced pancreatic polypeptide response to hypoglycemia and amylin response to arginine in subjects with a mutation in the HNF-4alpha/MODY1 gene.
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Academic Article
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Functional properties of the R154X HNF-4alpha protein generated by a mutation associated with maturity-onset diabetes of the young, type 1.
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Academic Article
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Beta-cell transcription factors and diabetes: no evidence for diabetes-associated mutations in the hepatocyte nuclear factor-3beta gene (HNF3B) in Japanese patients with maturity-onset diabetes of the young.
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Academic Article
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Fructose transporter in human spermatozoa and small intestine is GLUT5.
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Academic Article
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Calpains play a role in insulin secretion and action.
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Academic Article
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No diabetes-associated mutations in the coding region of the hepatocyte nuclear factor-4gamma gene (HNF4G) in Japanese patients with MODY.
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Academic Article
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Nuclear translocation of SHP and visualization of interaction with HNF-4alpha in living cells.
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Academic Article
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A 48-hour exposure of pancreatic islets to calpain inhibitors impairs mitochondrial fuel metabolism and the exocytosis of insulin.
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Academic Article
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Genetic variants of hepatocyte nuclear factor-1beta in Chinese young-onset diabetic patients with nephropathy.
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Academic Article
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Control of pancreas and liver gene expression by HNF transcription factors.
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Academic Article
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Transgenic mice with green fluorescent protein-labeled pancreatic beta -cells.
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Academic Article
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RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets.
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Academic Article
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Dual promoter structure of ZFP106: regulation by myogenin and nuclear respiratory factor-1.
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Academic Article
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Imaging Beta cell development in real-time using pancreatic explants from mice with green fluorescent protein-labeled pancreatic Beta cells.
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Academic Article
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Gene symbol: IPF1. Disease: MODY 4.
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Academic Article
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Calpain system regulates muscle mass and glucose transporter GLUT4 turnover.
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Academic Article
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Permanent neonatal diabetes due to mutations in KCNJ11 encoding Kir6.2: patient characteristics and initial response to sulfonylurea therapy.
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Academic Article
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Insulin gene mutations as a cause of permanent neonatal diabetes.
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Academic Article
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Subcellular recruitment by TSG118 and TSPYL implicates a role for zinc finger protein 106 in a novel developmental pathway.
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Academic Article
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Association of the (AU)AT-rich element polymorphism in PPP1R3 with hormonal and metabolic features of polycystic ovary syndrome.
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Academic Article
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From clinicogenetic studies of maturity-onset diabetes of the young to unraveling complex mechanisms of glucokinase regulation.
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Academic Article
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Variation in the perilipin gene (PLIN) affects glucose and lipid metabolism in non-Hispanic white women with and without polycystic ovary syndrome.
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Academic Article
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Obesity and hyperinsulinemia in a family with pancreatic agenesis and MODY caused by the IPF1 mutation Pro63fsX60.
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Academic Article
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Mutant proinsulin proteins associated with neonatal diabetes are retained in the endoplasmic reticulum and not efficiently secreted.
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Academic Article
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Calpain-10 gene and protein expression in human skeletal muscle: effect of acute lipid-induced insulin resistance and type 2 diabetes.
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Academic Article
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TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action.
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Academic Article
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Identification of two novel amino acid polymorphisms in beta-cell/liver (GLUT2) glucose transporter in Japanese subjects.
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Academic Article
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Human G-protein-coupled inwardly rectifying potassium channel (GIRK1) gene (KCNJ3): localization to chromosome 2 and identification of a simple tandem repeat polymorphism.
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Academic Article
|
Human thyroxine-binding globulin gene: complete sequence and transcriptional regulation.
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Academic Article
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Core transcriptional regulatory circuitry in human hepatocytes.
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Academic Article
|
Gi alpha 3 and G(o) alpha selectively associate with the cloned somatostatin receptor subtype SSTR2.
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Academic Article
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Mutation of an aspartate at residue 89 in somatostatin receptor subtype 2 prevents Na+ regulation of agonist binding but does not alter receptor-G protein association.
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Academic Article
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A molecular inventory of human pancreatic islets: sequence analysis of 1000 cDNA clones.
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Academic Article
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Localization of the gene encoding a neutral amino acid transporter-like protein to human chromosome band 19q13.3 and characterization of a simple sequence repeat DNA polymorphism.
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Academic Article
|
Localization of the genes encoding two transcription factors, LMX1 and CDX3, regulating insulin gene expression to human chromosomes 1 and 13.
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Academic Article
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G protein-activated inwardly rectifying potassium channel (GIRK1/KGA) mRNA in adult rat heart and brain by in situ hybridization histochemistry.
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Academic Article
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Stimulation of tyrosine phosphatase and inhibition of cell proliferation by somatostatin analogues: mediation by human somatostatin receptor subtypes SSTR1 and SSTR2.
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Academic Article
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Agonists and antagonists bind to different domains of the cloned kappa opioid receptor.
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Academic Article
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Glucokinase: structural analysis of a protein involved in susceptibility to diabetes.
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Academic Article
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Immunological detection of isoforms of the somatostatin receptor subtype, SSTR2.
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Academic Article
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Structure and function of ASP, the human homolog of the mouse agouti gene.
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Academic Article
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Somatostatin receptors, an expanding gene family: cloning and functional characterization of human SSTR3, a protein coupled to adenylyl cyclase.
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Academic Article
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Repression of the insulin-like growth factor II gene by the Wilms tumor suppressor WT1.
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Academic Article
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A single residue, aspartic acid 95, in the delta opioid receptor specifies selective high affinity agonist binding.
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Academic Article
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In vitro processing and secretion of mutant insulin proteins that cause permanent neonatal diabetes.
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Academic Article
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Organization of the human GLUT2 (pancreatic beta-cell and hepatocyte) glucose transporter gene.
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Academic Article
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Alterations in TCF7L2 expression define its role as a key regulator of glucose metabolism.
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Academic Article
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Genetic contribution of polymorphism of the GLUT1 and GLUT4 genes to the susceptibility to type 2 (non-insulin-dependent) diabetes mellitus in different populations.
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Academic Article
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Mutations in the hepatocyte nuclear factor-1alpha gene are a common cause of maturity-onset diabetes of the young in the U.K.
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Academic Article
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Localization of human homeodomain transcription factor insulin promoter factor 1 (IPF1) to chromosome band 13q12.1.
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Academic Article
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Nomenclature of the GLUT/SLC2A family of sugar/polyol transport facilitators.
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Academic Article
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Organ alchemy: producing insulin in the liver.
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Academic Article
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Insulin promoter factor-1 mutations and diabetes in Trinidad: identification of a novel diabetes-associated mutation (E224K) in an Indo-Trinidadian family.
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Academic Article
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5-amino-imidazole carboxamide riboside acutely potentiates glucose-stimulated insulin secretion from mouse pancreatic islets by KATP channel-dependent and -independent pathways.
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Academic Article
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Impaired insulin secretion in transgenic mice over-expressing calpastatin in pancreatic ß-cells.
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Academic Article
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Cloning of rat and mouse P2Y purinoceptors.
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Academic Article
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Regulation of expression of the human fructose transporter (GLUT5) by cyclic AMP.
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Academic Article
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Molecular model of human beta-cell glucokinase built by analogy to the crystal structure of yeast hexokinase B.
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Academic Article
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Cloning of a novel somatostatin receptor, SSTR3, coupled to adenylylcyclase.
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Academic Article
|
Dinucleotide repeat polymorphism at the human ribophorin II locus (RPN2) on chromosome 20q.
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Academic Article
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Classification and nomenclature of somatostatin receptors.
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Academic Article
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Molecular mechanisms of agonist-induced desensitization of the cloned mouse kappa opioid receptor.
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Academic Article
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A tyrosine phosphatase is associated with the somatostatin receptor.
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Academic Article
|
Inhibition of cell proliferation by the somatostatin analogue RC-160 is mediated by somatostatin receptor subtypes SSTR2 and SSTR5 through different mechanisms.
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Academic Article
|
Assignment of SLC6A9 to human chromosome band 1p33 by in situ hybridization.
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Academic Article
|
Structure and function of mammalian facilitative sugar transporters.
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Academic Article
|
Activation of human somatostatin receptor type 2 causes inhibition of cell growth in transfected HEK293 but not in transfected CHO cells.
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Academic Article
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Gi alpha 1 selectively couples somatostatin receptor subtype 3 to adenylyl cyclase: identification of the functional domains of this alpha subunit necessary for mediating the inhibition by somatostatin of cAMP formation.
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Academic Article
|
Persistence of two genotypes of Neisseria gonorrhoeae during transmission.
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Academic Article
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In vitro scan for enhancers at the TCF7L2 locus.
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Academic Article
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Purification of multiple heat shock proteins from a single tumor sample.
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Academic Article
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Role of BH3-only molecules Bim and Puma in ß-cell death in Pdx1 deficiency.
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Academic Article
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Cost-effectiveness of MODY genetic testing: translating genomic advances into practical health applications.
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Academic Article
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Microcephaly, epilepsy, and neonatal diabetes due to compound heterozygous mutations in IER3IP1: insights into the natural history of a rare disorder.
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Academic Article
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Evidence of non-pancreatic beta cell-dependent roles of Tcf7l2 in the regulation of glucose metabolism in mice.
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Academic Article
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Effect of genetic variation in a Drosophila model of diabetes-associated misfolded human proinsulin.
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Academic Article
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Genetic complexity in a Drosophila model of diabetes-associated misfolded human proinsulin.
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Academic Article
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Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms.
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Academic Article
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A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk.
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Academic Article
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A Loss-of-Function Splice Acceptor Variant in IGF2 Is Protective for Type 2 Diabetes.
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Academic Article
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Multiethnic Meta-Analysis Identifies RAI1 as a Possible Obstructive Sleep Apnea-related Quantitative Trait Locus in Men.
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Concept
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Bcl-2-Like Protein 11
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Grant
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MOLECULAR MECHANISMS/BETA CELL DYSFUNCTION IN DIABETES
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Grant
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A Fly Model of Complex Protein Misfolding Disease
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